![]() There was a high seroprevalence for SARS-CoV-2 specific neutralizing antibodies among RT-PCR negative contacts in workplace settings in Sri Lanka. Individuals with workspace exposure had significantly higher levels of neutralizing antibodies than those who did not (percentage neutralization in assay 63.3% (SD:21)vs 45.7% (SD:20), p = 0.0042), as did individuals who engaged socially without protective measures (62.4 (SD:21.6)% vs 49.7 (SD:21)%, p = 0.026). Primary risk factor associated with seropositivity was face to face contact with no mask for > 15 min ( p < 0.024, Odds Ratio (OR) 5.58, 95%CI 1.292– 25.65). Seroprevalences in the office setting, factory setting 1 and factory setting 2 were 69.2% (9/13), 55.7% (34/61) and 83.33% (15/18), respectively. The seroprevalence for SARS-CoV-2 specific neutralizing antibodies in the overall cohort was 63.04% (58/92). ![]() ![]() Serological samples collected six weeks post exposure were tested for anti-SARS-CoV-2 neutralizing antibody. The selected cohort that had been exposed to RT-PCR positive cases in the workplace was tested RT-PCR negative. A total of 92 unvaccinated individuals between the ages of 17–65 years were purposively sampled from an office and two factory settings. MethodsĪ cohort study was carried out in July 2021, during and immediately following the peak of the 3 rd wave of COVID-19 in Sri Lanka, prior to mass vaccination. While household and community-based studies have evaluated seroprevalence of antibody and transmission dynamics in this group, workplace-based data is currently unavailable. Asymptomatic SARS-CoV-2 infection occurring in RT-PCR negative individuals represent a poorly characterized cohort with important infection control connotations.
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